Day 1- August 13th

1:00am-2:00pm Registration

2:00-5:30pm Session I. Welcome and MISMS highlights

2:00-2:15    Welcome address (Nguyen Tran Hien, MD, MPH, PhD, National Institute of Hygiene and Epidemiology, Vietnam Ministry of Health, Vietnam)

2:15-2:30     Opening speech (Ministry of Health, Vietnam)

2:30-3:00     Overview of Multinational Influenza Seasonal Mortality Study; Integrating related mortality, virological, vaccine and genomic data to infer influenza epidemiology (Mark Miller, MD, NIH Fogarty International Center, US)

3:00-3:30     Seasonality of influenza in the Tropics and Southern Hemisphere (Wladimir Alonso, PhD, NIH Fogarty International Center, US/Brazil)

3:30-4:00 Coffee break

4:00-4:30   Control of influenza, increased vaccination rate and widespread use of neuraminidase inhibitors in Japan (Norio Sugaya, MD, Department of Pediatrics, Keiyu Hospital, Yokohama, Japan and Masayoshi Shinjoh, MD, Department of Pediatrics, School of Medicine, Keio University, Tokyo, Japan)

4:30-5:00     Overview of mortality impact from prior pandemics 1918, 1957 and 1968 (Lone Simonsen, PhD, George Washington University, US)

5:00-5:30     Transmissibility of epidemic and pandemic influenza and prospects for control (Cecile Viboud, PhD, NIH Fogarty International Center, US)

6:00-5:30     Reception at the Hilton Opera

Day 2 - August 14th, 2007

8:45-10:30am Session II. Modeling and international surveillance activities

8:45-9:15    Influenza surveilance in Asia Pacific regions: success, challenge, and way forward (Weigong Zhou, MD, PhD, WPRO, Philippines)

9:15-9:30    The South East Asia Influenza Clinical Research Network (Peter Horby, Director, Oxford University Clinical Resesearch Unit, Hanoi, Vietnam)

9:30-9:45    CDC model for estimates of influenza-associated morbidity and mortality (David Shay, MD, Centers for Disease Control and Prevention, US)

9:45-10:00    NIID Model for Excess Mortality due to Influenza in Japan (Yasushi Ohkusa, PhD, National Institutes of Infectious Diseases, Tokyo, Japan)

10:00-10:15     Methods for alerting the start of the annual influenza season (Ben Cowling, University of Hong Kong, Hong Kong)

10:15-10:30   Modeling the disease burden of influenza in the tropical / subtropical regions (Chit-Ming Wong, PhD, University of Hong Kong, Hong Kong)

10:30-10:50Coffee break

10:50am-12:30pm Session III. Investigator Reports, Influenza in tropical climates within Asia (part I)

10:50-11:15 Vietnam - Results of influenza surveillance in Vietnam (Nguyen Tran Hien, MD, MPH, PhD, National Institute of Hygiene and Epidemiology, Vietnam)

11:15-11:30 Vietnam - Some remarks on the two severe pneumonia cases were suspected to be caused by A(H5N1) influenza virus in Daknong province, Vietnam, February 2004 (Nguyen Thai, MD, Institute of Hygiene and Epidemiology of Tay Nguyen)

11:30-11:45 Tropical influenza: Global patterns of circulation and mortality impact (Cecile Viboud, PhD, NIH Fogarty International Center, US)

11:45-12:00 Singapore - Burden of seasonal influenza in Singapore (Stefan Ma, PhD, Ministry of Health, Singapore)

12:00-12:15 Singapore - Influenza historical pandemics in Singapore (Mark Chen or Angela Chow, Tan Tock Seng Hospital, Singapore)

12:15-12:30 Singapore - REDI center activities in support of prevention and control of avian influenza (Rodney Hoff, D.Sc., MPH, REDI Center, Singapore)

12:30-2:00pm Lunch provided at local restaurant - details available at the meeting

2:00-3:15pm Session IV. Investigator Reports, Influenza in tropical climates within Asia (part II)

2:00-2:15     Comparison of influenza associated mortality in three Asian tropical / subtropical cities (Lin Yang, University of Hong Kong)

2:15-2:30     Taiwan - Mortality associated with influenza in Taiwan (Jen-Hsiang Chuang, MD, PhD, Centers for Disease Control, Taiwan)

2:30-2:45     Thailand - Initiation of a Respiratory Illness Surveillance System in the Royal Thai Army (Jariyanart Gaywee, PhD, Armed Forces Research Institute of Medical Sciences (AFRIMS), Thailand)

2:45-3:00   Thailand - Seasonal influenza, examples from Thailand (Scott Dowell, MD, MPH, International Emerging Infections Program, Thailand Ministry of Public Health, US CDC Collaboration)

3:00-3:15  Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) lower respiratory infections (LRI) in underfive children in Bandung, Indonesia (Eric Simoes, MD, DCH, University of Colorado School of Medicine, US)

3:45-4:15pm Session V. Vaccine issues

3:15-3:30   Evidence of vaccine benefits: from excess mortality to clinical trials (Lone Simonsen, PhD, George Washington University, US)

3:30-3:45   Review of influenza vaccine immunogenicity studies (Jessica Seidman, MHS, NIH Fogarty International Center, US)

3:45-4:00   Evaluation of the southern hemisphere influenza vaccine recommendations (Stephanie Richard, MHS, NIH Fogarty International Center, US)

4:00-4:15   Progress to achieve the GAP (Global Pandemic Influenza Action Plan (Lara Wolfson, PhD, MS, WHO, Initiative for Vaccine Research, Switzerland)

4:15-4:35 Coffee break

4:35-6:00pm Session VI. Molecular epidemiology and evolution

4:35-4:45     US - Overview of the NIH genomic sequencing project and insights gained to date (Lone Simonsen, PhD, George Washington University, US)

4:45-5:10     Evolutionary genetics of the influenza virus; Lessons learned from sequencing studies (Eddie Holmes, PhD, Pennsylvania State University and NIH Fogarty International Center, US)

5:10-5:35     Global patterns in the evolution and epidemiology of influenza A(H3N2) virus from 2002 to 2007 (Colin Russell, PhD, University of Cambridge, United Kingdom)

5:35-6:00     Ecology and evolution of influenza A (H5N1) virus in Asia (Gavin Smith, PhD, Hong Kong University, Hong Kong

Day 3 - August 15th, 2007

8:45-10:15am Session VII. Investigator Reports. Influenza in temperate climates within Asia

8:45-9:00   Australia - WHO Influenza surveillance in Australia (Heath Kelly, University of Melbourne, Australia)

9:00-9:15   Australia - Influenza-related hospitalization and death in Australians aged 50 years and older (Tony Newall, MPH, The University of Sydney / The National Center of Immunisation and Surveillance, Australia)

9:15-9:30   New Zealand - Influenza Surveillance Activities in New Zealand (Lance Jennings, PhD, Canterbury District Health Board, New Zealand)

9:30-9:45 Republic of South Korea - Influenza-Associated Mortality in Korea (Jong-Won Kang, MD, MPH, Chungbuk National University College of Medicine, South Korea and NIH Fogarty International Center, US)

9:45-10:00 Japan - The 1918 pandemic influenza experience: Age and geographic mortality patterns (Stephanie Ann Richard, MHS, NIH Fogarty International Center, US)

10:00-10:15 Japan - Impact of influenza control strategies on seasonal mortality in the Japanese senior population, 1995-2006 (Katherine Sturm-Ramirez, PhD, NIH Fogarty International Center, US)

10:15-10:45 Coffee break

Session VIII. Closing 10:45am-12:00pm

• Putting it all together - integrating molecular, vital statistics and immunogenicity data to help formulate influenza control strategies. Role of computational biology and historic data to inform epidemic and pandemic control of influenza. Further steps to collaboration (Mark Miller, MD, NIH Fogarty International Center, US)
• Discussion

12:30-2:00pm Lunch provided at local restaurant - details available at the meeting

2:00-5:30pm Workshop (optional for meeting-only participants, required for workshop participants)