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MISMS Research Workshop on Influenza at the animal-human interface

Padua, Italy
Feb 25 - Mar 01, 2013


 


 

Co-hosted by the Fogarty International Center of the U.S. National Institutes of Health (NIH) and the Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe).

 

 

This was the eleventh regional meeting held as part of the FIC-initiated Multinational Influenza Seasonal Mortality Study (MISMS), an international research collaboration that analyzes epidemiologic and phylogenetic patterns associated with influenza virus circulation. This workshop will be focused on the ecology, epidemiology, evolution and transmission dynamics of influenza viruses at the human-animal interface, including, but not limited to, swine and avian viruses. Past meetings/workshops have been held at the NIH and in South America (Argentina, Peru), Asia (Nepal, China, and Vietnam), Europe (Portugal and Denmark), Africa (Senegal), and Oceania (Australia). These meetings have been designed to help build analytical capacity for epidemiologic and molecular studies of influenza, identify potential collaborators, and disseminate new scientific findings that may serve to inform influenza control strategies.  These meetings have been designed to help build analytical capacity for epidemiologic and molecular studies of influenza, identify potential collaborators, and disseminate new scientific findings that may serve to inform influenza control strategies.

The research workshop in Padua, Italy was intended for public health officials, epidemiologists, veterinarians, and virologists who conduct research on influenza and other respiratory diseases at the human-animal interface. Participants would also have a forum to discuss research findings and methodologies, as well as the opportunity to review and evaluate their data utilizing new analytical techniques.

The first two days of the meeting (Feb 25-26) featured scientific presentations by MISMS collaborators and meeting participants on research methodologies and results related to influenza at the human-animal interface. Topics of interest included influenza phylogenetic and molecular analyses, virus surveillance, vaccine and control strategies, risk of emergence of zoonotic viruses, spatio-temporal transmission dynamics in animal and human hosts, contact and migration patterns, and other human and animal health issues.

The second part of the meeting (Feb 27-Mar 1) consisted of technical workshops during which MISMS staff assisted collaborators with the analysis of their own influenza data. Attendance to the workshop is open to those with an interest in mathematical and statistical modeling of epidemiologic and virologic data, as well as the analysis of phylogenetic and antigenic data.


Venue

Hotel Plaza Padova, Corso Milano, 40 - 35139 Padova, Italy


Agenda

Morning Afternoon

Welcome and MISM overview

Session I

Session II

Session III

Session IV

Session V

Session VI

Conclusions and options for Future Collaborations

Technical Workshops Time-series analyses

Technical Workshops Phylogenetics

Data-set presentations

Thursday, Feb 28

Technical Workshops Hands-on tutorials

Technical Workshops Hands-on tutorials

Friday, March 1

Technical Workshops Hands-on tutorials

Closing remarks

 

 


Detailed Agenda

Day 1- Monday, February 25: Scientific Presentations

8:30-9:00 Registration and Welcome Coffee (30')

(All presentations will be 15 minutes with 5 minutes at the end for questions, unless otherwise noted)

09:00-10:00 Welcome and MISMS overview

- Mark Miller, Fogarty International Center, USA

- Giovanni Cattoli, IZSVe, Italy

- Ilaria Capua, IZSVe, Italy : Influenza viruses at the human-animal interface

10:00-11:20 Session I: Influenza viruses at the animal-human interface.

Chairs: Giovanni Cattoli, IZSVe and Eddie Holmes, University of Sydney

- Andrew Bowman, 'The Ohio State University: 'Detection of influenza A virus in swine at US agricultural exhibitions'

- Juan Cristina, Facultad de Ciencias, Uruguay: 'Evolution of influenza viruses in humans and swine in South America'

11:20-11:50 Coffee break (30')

11:50-12:50 Session II: Modeling influenza dynamics in animals

Chairs:Cecile Viboud, FIC and Ilaria Capua, IZSVe

- Tavis Anderson, US Department of Agriculture: ‘Using network theory to identify viruses for antigenic characterization and vaccine design in swine’

- Chiara Poletto, ISI Foundation, Italy: ‘Host mobility drives competition in host-multipathogen systems’

- Arianna Comin, IZSVe: 'Evaluating surveillance strategies for the early detection of low pathogenicity avian influenza infections by means of simulation models'

12:50-14:20 Lunch break (90')

14:20-15:20 Session III. Avian influenza

Chairs: Martha Nelson, FIC and Alice Funaro, IZSVe

- Abdelsatar Arafa, Animal Health Research Institute, Egypt: ‘Evolution of avian influenza H5N1 viruses in Egypt’

- Jacqueline Nolting, Ohio State University: ‘Avian influenza at the zoological-wild bird interface in northern Ohio’

- Paolo Mulatti, IZSVe, Epidemiological analysis of 1999 H7N1 HPAI Epidemic in Italy

15:20-15:50 Coffee break (30')

15:50-17:10 Session III, continued, with focus on Bangladesh

- Nancy Gerloff, Centers for Disease Control and Prevention, USA: ‘Genomic
diversity of two new clades of highly pathogenic avian influenza A (H5N1) in  Bangladesh’

- Ireen Shanta, International Centre for Diarrheal Disease Research, Bangladesh (icddr,b): ‘Backyard poultry rearing practices in Bangladesh: implications for risk of avian influenza’

- Najmul Haider, International Centre for Diarrheal Disease Research, Bangladesh: ‘Risk factors for A/H5N1 avian influenza outbreaks in Bangladesh’

- Ausraful Islam, International Centre for Diarrheal Disease Research, Bangladesh: ‘How far can influenza-infected waterfowl fly?’

Day 2- Tuesday, February 26

09:00-10:20 Session IV. Spatial and evolutionary dynamics of influenza viruses in animals

Chairs: Wladimir J. Alonso, FIC and Juan Cristina, Facultad de Ciencias

- Eddie Holmes, University of Sydney: Molecular epidemiology of influenza viruses  (25’ + 5’)

- Alice Fusaro, IZSVe : ‘Molecular epidemiology of avian influenza viruses’ (25’ + 5’)

- Marha Nelson, Fogarty International Center: 'Influenza at the human-swine interface: it takes two to tango'

10:30-11:00 Coffee break (30')

11:00-11:30 Session IV, continued

- Andrew Rambaut, University of Edinburgh, TBD (25’ + 5’)

11:30-13:00 Lunch break (90')

13:00-14:00 Session V. Influenza in Humans

Chairs: Isabella Monne, IZSVe and Diane Gross, WHO-EURO

- Rodolfo Acuña-Soto, Universidad Nacional Autonoma de Mexico: Constant large-scale geographic patterns of seasonal influenza mortality in continental US and Mexico’*

- André R Ribas Freitas, UNICAMP, Brazil: ‘Influenza-associated mortality in Brazil during
pre-pandemic, pandemic, and post-pandemic periods’ and ‘Difference of the
impact of the first two waves of the 1918 pandemic influenza among the four
largest cities in the state of São Paulo: clues of the importance of climatic factors. (20’ + 5’)

- Wladimir J. Alonso, Fogarty International Center, US: Climate and the seasonality of human influenza: a conundrum across latitudes (15’ + 5’)

14:30-15:30 Short dataset presentations (5 min each)

15:30-16:00 Break (30')

16:00-16:30 Short dataset presentations (5 min each)

16:30-17:00 Conclusions and options for Future Collaborations

- Mark Miller, Fogarty International Center, USA

 

Day 3- Wednesday, February 27: Workshop

Beginning of the technical workshop

09:00-10:30 Time-series analyses I

- Wladimir J Alonso, Fogarty International Center, USA: Practical in time-series, spatial analysis methods and tools, data visualization (link to the analytical program EPIPOI)

10:30-11:00 Coffee break

11:00-12:00 Time-series analyses II

- Cecile Viboud, Fogarty International Center, USA: Reproduction number estimation and disease modeling

12:00-13:30 Lunch break

13:30-14:30 Phylogenetics 101

- Eddie Holmes, University of Sydney: Molecular epidemiology of influenza viruses  (25’ + 5’)

14:30-15:00 Coffee break

15.00-16.00 Bayesian evolutionary analysis

- Andrew Rambaut, FIC, Introduction to the BEAST software package for Bayesian methods in phylogenetics. 101

16.00-17.00 Working time

 

Day 4- Thursday, February 28: Workshop

Hands-on tutorials, small group collaboration, one-on-one instruction

9:00-17:00  Workshop

Day 5 - Friday, March 1: Workshop

Hands-on tutorials, small group collaboration, one-on-one instruction

9:00-12:30  Workshop

12:30 Closing remarks

- Cecile Viboud, Fogarty International Center, USA

 

For more information about about MISMS, please contact us at ficmisms@mail.nih.gov.


 

 
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